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PGC-1 repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium

Unlike ascorbic acid, tetrahexyldecyl ascorbate is more stable

E.StevensB

It is worth noting that while this hAOX metabolism was observed in this study, the half-lives of the compounds screened in human liver cytosol were high (90 minutes), and therefore further work is needed to establish the relevance of hAOX metabolism in the overall clearance of PROTAC molecules