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Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat

In addition, P53 could downregulate the SLC7A11 expression to inhibit cystine uptake, thereby affecting GPX4 activity and ultimately promoting the occurrence of ferroptosis ( in vivo , whereas SLC7A11 / embryonic fibroblasts underwent cell death in routine culture medium in vitro but could proliferate normally in the presence of 2-mercaptoethanol (2ME), N-acetyl cysteine (NAC), or vitamin E (Stipanuk, 2004

Rangan C, Barceloux DG

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Furthermore, iron overload can promote the production of ROS in T cells, which leads to DNA damage and undermines the responsive ability of T cells, thus expediting the pathological process of inflammation (119)