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Thus, the clinical and experimental studies convincingly show the involvement of mitochondrial abnormalities in RS, although the mechanisms underlying the role of mitochondrial dysfunction need further investigation

Together, these findings unveil ACase as a novel regulator of the ferroptosis pathway and open promising therapeutic avenues for targeting senescence-linked disorders and advancing healthy aging strategies.

Efficacy and safety of sphingosine-1-phosphate receptor modulators in the management of inflammatory bowel disease: a systematic review and meta-analysis