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In an 8-week, randomized, placebo-controlled trial in patients with recent-onset schizophrenia or a related disorder, use of adjunctive pregnenolone, taken orally, at a dose of 50 mg/day was shown to result in a significant improvement in executive functions as well as visual and sustained attention

Kang, et al

Its regulation both at a genetic level (both transcriptional and translational) and a biochemical level (post-translational) is incredibly complex

Preclinical studies with PARP inhibitors in GBM showed encouraging results, such as improved radiosensitivity in cells, effectiveness in sensitizing irinotecan- and temozolomide-resistant tissues, reduced growth of GBM cells, and improved survival in animal models [159]

A.WangX.ChanJ