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Identifying patients with unfavorable prognoses in a timely manner and establishing straightforward and reliable prediction methods in everyday clinical settings are essential to provide optimal treatment in healthcare facilities

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CRC cells were treated with -amanitin to block RNA synthesis and CHAC1 mRNA degradation was tested over a 15 h period

IR exerts important regulatory effects on ovarian function, endometrial health and glucose-lipid metabolism in patients with PCOS, serving as a primary contributor to infertility and unfavorable long-term outcomes in reproductive-aged females