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Notably, 5-fluorouracil (5-FU), a key chemotherapeutic for CRC, also shows strong antimicrobial activity against Fusobacterium nucleatum (Fn), a bacterium linked to poor prognosis and chemoresistance (LaCourse et al., 2022)

Likewise, PKC has been shown to directly target phosphorylation of serine 490 of occludin, promoting ubiquitination and degradation of tight junctions in bovine retinal endothelial cells (96)