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Howes, Oliver D., et al

However, none of the therapeutic candidates have been successful so far [10-12] , with the major impediment for most being a failure to cross the blood-brain barrier

In Arbutin_a, arbutin additionally forms hydrogen bonds with H84, H263, and V282, which collectively stabilize arbutin in the pockets upper side (Fig

PubMed , Frontiers in Molecular Neuroscience , vol

Interestingly, even infectious entities with little to no CNS penetrance can stimulate inflammatory responses within the brain parenchyma, suggesting a role for systemic inflammation in the etiopathogenesis of neuroinflammation