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Regulatory and systemic response processes

Nutritional deficiencies need to be considered first as differentials in pancytopenia, even in the absence of typical signs of vitamin B12 deficiency (like macrocytosis and hypersegmented neutrophils) and in the presence of compelling clinical indications pointing to a hematologic malignancy

Nature Reviews Molecular Cell Biology , 21(12), 735-750

Despite antioxidants pharmacological properties were reported in vitro and in vivo , some of the clinical expectations of antioxidant-based therapies have been frequently disappointed