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503A compounding pharmacies may work with materials which, in addition to being accompanied by a valid certificate of analysis (CoA) and manufactured in an FDA registered facility, must meet one of the below three requirements: Complies with an applicable USP or NF monograph if one exists* Is a component of an FDA-approved drug product if an applicable USP or NF monograph does not exist

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This process regulates intestinal calcium and phosphorus absorption, promotes bone mineralization, maintains calcium and phosphorus homeostasis, and participates in physiological processes such as immune regulation, cell proliferation, and differentiation, thereby safeguarding human health ( 2 D 3 inhibits the activity of CYP2R1 in the liver and 1-hydroxylase in the kidney via a negative feedback mechanism, thus preventing excessive vitamin D synthesis and activation, and maintaining vitamin D metabolic homeostasis ( Figure 2 )