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Among these, enhancing fat metabolism to spare glycogen reserves is particularly interesting, especially in long-duration events

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Synergistic metabolic effect Some products contain ingredients such as caffeine and methylnicotinate esters, which can activate adenylate cyclase (AC), increase intracellular cAMP levels, and thereby activate hormone-sensitive lipase (HSL), accelerating fat mobilization

Adverse Events Of the 15 trials, four did not report adverse event (AE) data