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Whether administration of leptin could overcome leptin resistance and exert an anti-obesity effect was tested in a placebo-controlled study with 47 obese men and women given varying doses of recombinant human leptin (0.03 mg/kg and 0.30 mg/kg, respectively) for 24 weeks and advised to eat 500 kcal less than body requirements each day

According to several retrospective investigations, the general public's understanding of homocysteine as a hazard factor is still unclear among subjects with increased homocysteine levels who also have chronic kidney disease (CKD) and end-stage renal disease (ESRD)

Follow up after 12 years in both cases demonstrated partial recovery

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Fertility, pregnancy and lactation