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The ingredients in supplements, including vitamins, minerals, herbs, and other botanicals, can have unintended negative consequences when combined with some medications, other supplements, foods, and alcohol ( For example, vitamin E supplements may increase the risk of bleeding in those on blood-thinning medications, while calcium supplements may limit the effectiveness of antibiotics and reduce the absorption of iron from foods and supplements ( Some supplements may also affect the accuracy of lab results

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Of note is the observation that one of the several proteases the schistosome gut produces for digestion of RBCs, cathepsin D, is also capable of cleaving IgG and complement component C3, although it is not known if this functions as an immune evasion technique for combatting gut permeabilization or is rather just part of digesting these factors as possible nutrient sources (167)

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