Mechanism of Action and Target Biology NNMT Enzyme and Function: Nicotinamide N-methyltransferase (NNMT) catalyzes the SAM-dependent methylation of nicotinamide: Reaction: Nicotinamide + SAM 1-methylnicotinamide (1-MNA) + S-adenosylhomocysteine (SAH) Expression: Liver, adipose tissue (particularly visceral), smooth muscle, some neurons Regulation: Increased expression in obesity, diabetes, aging, certain cancers Substrates consumed: Nicotinamide (NAD+ precursor) and SAM (methyl donor) 5-Amino-1MQ Inhibition Mechanism: Competitive inhibitor with respect to nicotinamide substrate IC: Submicromolar range for NNMT enzyme Selectivity: Minimal inhibition of other methyltransferases at relevant concentrations Result: Increased intracellular nicotinamide availability for NAD+ salvage pathway Downstream Effects of NNMT Inhibition: 1
This ceiling effect is important
People following a vegetarian or vegan diet, however, should be aware that they are at a higher risk of B12 deficiency due to this lack of B12 in plant foods
While most people tolerate B12 shots well, it is always best to stay in communication with a qualified medical team
Likewise, in some special cases and even having made the respective monetary deposit, the reconfirmation of the reservation must be awaited due to restrictions or regulatory conditions in the country of a service provider
