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Review papers which looked at the few available clinical trials have not offered any clear guidelines for the clinician seeking advice on best practice for the management of patients with hyperpigmentation

FIGURE 4 Effect of TLYY administration on gut microbiota in DSS-induced mice Natural active products can ameliorate ulcerative colitis (UC) through modulation of the gut microbiota

PloS One (2013) 8(2):e56567

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial