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J Ethnopharmacol 146(3):815823 Goh YS, Karunakaran T, Murugaiyah V, Santhanam R, Abu Bakar MH, Ramanathan S (2021) Accelerated solvent extractions (ASE) of Mitragyna speciosa Korth (Kratom) leaves: evaluation of its cytotoxicity and antinociceptive activity