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The first was a randomized trial of 206 subjects treated with intravenous infusions of either edaravone or placebo for 24 weeks (Abe 2014)

Supporting Information References 1.Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/ChronicFatigue Syndrome, Board on the Health of Select Populations, Institute of Medicine in Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (National Academies Press, U.S.A., 2015)

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Extracellular signal-regulated kinase (ERK)-mediated phosphorylation of MFN1 (HR1 domain) suppresses fusion and promotes apoptosis, whereas JNK phosphorylation of MFN2 targets it for ubiquitination by E3 ligases and proteasomal degradation, resulting in mitochondrial fragmentation and increased apoptosis

Vitamin B injections offer a direct path to supporting detox pathways, reducing toxic burden , and improving resilience to stress and inflammation