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Conversely, excessive copper promotes A aggregation, tau hyperphosphorylation and ROS generation, thereby accelerating neurodegenerative processes (256,257,260)

The prevalence of antineutrophil cytoplasmic antibodies (ANCAs), anticardiolipin antibodies, and antinuclear antibodies (ANAs) in patients with PSC is 84%, 66%, and 53%, respectively (Angulo et al, 2000)