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Anti-inflammatory effects reducing chronic dry eye inflammation

Rotate injection sites between uses to prevent local irritation or lipodystrophy

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This is of significance since although corticosteroid use has long been and remains controversial for healing of tissues (Carrico et al

50,51 While necroptosis enhances antigen availability, leukocyte infiltration, and DC cross-presentation, the robust induction of cytokines such as IL-12 and IL-15 generally depends on additional PRR engagement or proinflammatory cues that fully activate DCs via nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and interferon regulatory factor (IRF) signaling pathways