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SIRT3, a class III HDAC associated with longevity, deacetylates Forkhead box protein O3a (FOXO3a) and promotes transcription of antioxidant enzymes (e.g., manganese superoxide dismutase and catalase), thereby constraining mitochondrial ROS and preserving redox homeostasis [71, 72]

Histopathologic analysis of the colonic biopsies confirmed the presence of severe melanosis

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The anti-obesity impact of polysaccharides in dark tea (hmtp) correlates strongly with shifts in the relative abundance of gut microbiota, particularly with marked increases in Dubosiella and Romboutsia, which inversely correlate with body weight and positively with the IBAT index