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The possible mechanisms for the development of DM may be due to iAS interference with insulin-stimulated signal transduction pathway 123 or during acute poisoning, arsenite inhibits pyruvate and -ketoglutarate dehydrogenases enzymes which are essential for gluconeogenesis and glycolysis 124

In animal model studies, it has been shown to extend the average lifespan by 2530% , while simultaneously improving physical performance and stress resistance

Regulation of the intrinsic apoptosis pathway by reactive oxygen species

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