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Injection into sensitive or low-fat tissue: Areas such as the abdomen, inner thigh, or other sites with minimal subcutaneous fat have less tissue cushioning and a higher density of sensory nerve endings, making pH-related discomfort more noticeable

None of these is a footnote each is a reason a real prescribing decision would require individual medical assessment rather than a generic protocol

With other antihypertensive drugs, the possibility of potentiation should be considered, although interaction has not been clinically proven

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