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Graves Disease Symptoms People who have Graves disease often have one or more of the following symptoms: Bulging, gritty, irritated eyes (Graves ophthalmopathy) Enlarged thyroid (goiter) Fast or irregular heartbeat Fatigue Frequent bowel movements Heat intolerance Irritability Nervousness Shaky hands Sweating Trouble sleeping Weak muscles Weight loss, even when you have increased hunger Diagnosing Graves Disease Its always important with any question or concern about thyroid health to get the full panel of thyroid hormones checked and not just TSH, which is typically the only thing measured in conventional lab tests