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Joe Burrascano: In the very early days, we did not

10.1080/09168451.2017.1364965 69 JohnsonD

Paget observed that primary tumor cells of a given type of cancer preferentially metastasized to one or more particular distant organ sites, detectable metastases only developed at those sites (soils) where the tumor cells (seeds) were adapted for survival and proliferation [21]

The clinical challenges associated with NSCLC, such as metastatic spread and therapeutic resistance, underscore the need for novel approaches to treatment, including those that address the underlying biology of the disease [3,4,5]

As we age, there are areas in the brain that become poorly perfused, meaning there is not enough blood flowing through those areas