These include the types of Cys-oxidations of interest, number of biological samples, selection of approaches (reactive thiols or oxidized Cys), incorporation of chemical tags, enrichment method, availability of antibodies, and type of quantitation ( Types of Oxi-Cys PTMs of interest (global or selected PTMs as seen in Figure 1) to ensure that, in the case of selected Oxi-Cys, the (affinity) purification method is available and suitable
When analyzing the available data, it can appear that controlling any specific deviation from the norm by altering the cells redox status should be quite simple because so many processes are taking place at the expense of proteins and other molecules undergoing redox transformations [5]
Reported side effects are rare and typically mild: mild redness or irritation at the application site (usually resolves with continued use or concentration adjustment), occasional skin tingling at higher concentrations (typically benign), and temporary dryness during initial use
caerulescens seems to be an excellent model to understand the adaptive significance of this phenomenon
Optimization of the composition and functionality of the gut microbiota by diet and supplementation in SLE could present an alternative therapeutic strategy to conventional management