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Resistin promotes cardiac hypertrophy via the amp-activated protein kinase/mammalian target of rapamycin (ampk/mtor) and c-jun n-terminal kinase/insulin receptor substrate 1 (jnk/irs1) pathways

Nevertheless, in animal models of ischemic AKI, the involvement of PAD4 in NETs formation leads to post-ischemic kidney damage, suggesting a potential therapeutic significance of PAD4 inhibitors in post-ischemic kidney injury (103)

Indeed, restoration of apoE expression only to the periphery improves cognition and restores synaptic defects in APOE KO mice, suggesting that plasma apoE/lipid levels can influence cognition and synaptic function independent of apoE expression in the CNS [238]

[DOI] [PubMed] [Google Scholar] 99.Gupta S., Wairkar S., Bhatt L.K

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