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These metabolic changes often appear years before irreversible structural atrophy occurs, making them invaluable for early detection ( 4.2 Brain insulin resistance (Type 3 diabates) A controversial but intriguing concept for understanding Alzheimer's disease (AD) is the Type 3 Diabetes (T3D) hypothesis, which suggests that AD may be a form of brain-specific insulin resistance

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Key strategies include gradual exposure and desensitization, modeling and social stories, choice, and control, reinforcement, and rewards, and task analysis and shaping[286]