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AGEs are product from the non-enzymatic reaction of the amino groups in proteins, lipids, and nucleic acids with the carbonyl groups of reducing sugars

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In addition, Matesanz-Snchez et al.s study showed that a decrease in EXT2 levels can cause dysregulation of lipid metabolism and antioxidant capacity by altering SAM and transsulfuration pathway enzymes levels, triggering lipid peroxidation and ultimately leading to ferroptosis in GBM cells [12]

doi: 10.1124/jpet.108.149815 110 ZhangYGLuRWuSChatterjeeIZhouDXiaYet al