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In the pathology of OA, cellular iron overload can increase localized inflammatory mediators, contributing to OA development ( 2.2 Lipid peroxidation A disruption of cell membrane integrity, which can lead to cell death, represents one potential mechanism through which ferroptosis occurs

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These genes promote acylation metabolism and mediate downstream oxidative stress and inflammatory responses by sensing copper ion stress and the outward transport and excretion of copper

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