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Research has shown that MSCs modified with synthetic miRNAs can improve the sensitivity of cancer cells to chemotherapy by transferring specific miRNAs through Exos [178,179,180]

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EXOs have been found to co-precipitate with other cellular components, including other extracellular vesicles, protein clumps, and even extremely abundant proteins, in a variety of biofluids such as plasma and serum

Further large-scale, long-term longitudinal trials are required to confirm whether these microbiota-based interventions directly translate into a reduced risk of clinical fracturesthe ultimate gold standard for OP treatment