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Various irreversible changes that occur include fragmentation and aggregation of proteins and lipids

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Additionally, we classify metabolites according to possible categories of therapeutic intervention, and summarize the latest preclinical and clinical data unveiling the roles of intestinal metabolites in the pathophysiology of major diseases of the gastrointestinal tract, including inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, enteric infection, food allergy, coeliac disease, as well as obesity and metabolic syndrome

Effect of tea catechins on gut microbiota in high fat diet-induced obese mice