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The major ferroptosis-related pathways influenced by polysaccharides are the SLC7A11/GSH/GPX4 pathway, Keap1/Nrf2/HO-1 pathway, NCOA4-mediated ferritinophagy pathway, ACSL4-mediated lipid peroxidation pathway, and their upstream signal such as PI3K/Akt, Wnt/-catenin, p53, and the AMPK/BECN1 autophagy pathway

The problem the search results promise to solve is real when illness, age, or environmental load push oxidative stress higher than the body can recycle glutathione, detox capacity falls behind and inflammation climbs

7 B12 deficiency is associated with neuropsychiatric symptoms and may be of particular relevance to refugees, many of whom have a background of psychological ill-health related to torture and trauma

The fluorogenic assays followed the same protocol as described for cathepsin B

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