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Its deficiency leads to a decrease in the erythrocyte concentration of 2,3-BPG and, consequently, an increase in the affinity of hemoglobin for molecular oxygen

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Zhao W, Zhang L, Zhang Y, Jiang Z, Lu H, Xie Y, et al

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MTHFR C677T and colorectal cancer risk: a meta-analysis of 25 populations

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Science (2017) 357(6349)

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Biochem Pharmacol 58:17651773

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