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Combining compounds with distinct mechanisms requires careful dose titration and physiological monitoring

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Nevertheless, FSP1 has been less studied in the heart, where its relationship with ferroptosis and its precise function are poorly understood

Metabolite quantification was acquired using Barstool [52] (see Supplementary Fig

(3) an alternative condensation of -glutamyl phosphate synthesized by -glutamyl kinase (Pro1 or ProB) with cysteine to form -glutamylcysteine which was further conjugated to glycine by glutathione synthetase