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Relevant behavioral tests include the buried food or olfactory habituation/dishabituation tests for assessing olfactory function [142], as well as tasks probing executive functions such as decision-making and inhibitory control (delay discounting, five-choice serial reaction time task) [143, 144], working memory (delayed alternation task) [145], attention (attentional set-shifting task) [146], and behavioral flexibility (reversal learning task) [147], which are heavily dependent on prefrontal cortex activity

Concurrently, elevated DCA and LCA activate GPCRs (e.g., TGR5) to trigger -catenin-dependent upregulation of CCL28, selectively expanding intratumoral immunosuppressive Tregs to reinforce immune evasion (241)

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