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Changes in expression of DNA methyltransferases, which methylate CpG sites of DNA, have been implicated as a mechanism for remodelling the epigenome in response to acute UPEC infection 31 , potentially explaining how a previous infection, whether self-resolving or chronic, could alter the USC epigenome

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c , Intracellular flow cytometry using the anti-P2RY8 antibody from b , which binds the C terminus of P2RY8, on empty vector-GFP- or P2RY8-GFP-transduced WEHI-231 (mouse) cells, compared with rabbit isotype control or no primary antibody staining conditions