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Other sites within mitochondria known to generate O 2 that are gaining biological significance include pyruvate dehydrogenase, -ketoglutarte dehydrogenase, glycerol 3-phosphate dehydrogenase, and proline dehydrogenase

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A limitation of the prevalence of their use is high cost of production and validation, as well as lack of standardized laboratory platforms to assess them

A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation

Given that ferroptosis is currently a research focus that attracts much attention, roles of more E3 ligases in regulating ferroptosis will be explored in the recent futures