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Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms

Moreover, the concurrent pharmacological inhibition of PIK3C3/VPS34 with anti-PD-1/PD-L1 therapy amplifies the therapeutic response, demonstrating proof-of-concept for novel clinical trials designed to surmount resistance in cold, IC-unresponsive tumors via dual treatment with PIK3C3/VPS34 inhibitors and ICIs (179)