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The currently employed validated clinical models, such as photodamage, NaIO, and STZ mouse models, cannot completely mimic the chronic, multifactorial pathogenic environment of human AMD/DR, and the extrapolation of efficacy is questionable

Barrier pathophysiology in development 3.1 Pediatrics The intestine at birth is not fully developed and many factors, such as diet, stress and microbiota have been implicated in influencing its permeability during development [50][51][52]