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Storage duration critically impacts effectiveness - reconstituted GHK-Cu lasts only 21-28 days refrigerated due to copper oxidation concerns (shorter than most peptides), requiring strategic reconstitution of amounts usable within this window rather than preparing entire vials at once

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A GHK-Cu eye cream, tested on 41 women for twelve weeks with mild to advanced photodamage, was compared to a placebo control and an eye cream containing vitamin K