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Here, we found that the neuronal conditional-knockout (KO) of glutamyl-cysteine-ligase catalytic-subunit (GCLC), a rate-limiting enzyme for glutathione synthesis, induced brain atrophy accompanied by neuronal loss and neuroinflammation

The primary objective was to assess the ameliorative potential of orally administered substances, including 50 mg/kg body weight clomiphene citrate (control), chemically synthesized AgNP, Nigella sativa seed extract, and Nigella sativa -mediated AgNP, against the toxic effects of Cr (VI) induced by oral administration of K2Cr2O7 at a dose of 1.5 mg/kg body weight over eight weeks

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doi: 10.1016/s0196-9781(01)00633-7 45 ArmandMHamoshMMehtaNRAngelusPAPhilpottJRHendersonTRet al

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