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Changes in the BBB associated with Alzheimer's disease primarily include endothelial abnormalities such as reactive gliosis, mitochondrial damage, alterations in the extracellular matrix, disrupted tight junctions, and both molecular and functional changes in astrocytes

However, it is known that the placental dysfunction is often gradual and it can occur much earlier than any demonstrable IUGR[188], thus difficulting the resolution of this hypothesis

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The depth of the melanoma or the Breslows depth, a measure of how deep the melanoma has penetrated into the skin, is a crucial factor

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