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E., Kanikarla-Marie, P

As a result of the suppressed levels of catalase, there is an increased concentration of hydrogen peroxide, which can be further decomposed to hydroxyl radicals by a photochemical reaction (Schallreuter et al

M.LeungS

To investigate the function of CBS in this process, we silenced its expression by CRISPR/cas9 mediated gene knockout strategy (sg CBS ) in SCD erythroblasts (Fig