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Hence, the low levels of thiomethyl metabolites observed after APAP exposure are probably associated to the limited cytochrome P450 capabilities of in vitro models to generate NAPQI metabolites via CYP2E compared to in vivo hepatocytes

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10.1093/gerona/glr208 [DOI] [PMC free article] [PubMed] [Google Scholar] Dammann P., umbera R., Massmann C., Scherag A., Burda H

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