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If a GLP-1 medication is accidentally left out of the refrigerator before first use, the appropriate action depends on the duration and temperature of exposure

10.1021/acs.jmedchem.6b01890 91 MpakaliA.SaridakisE.HarlosK.ZhaoY.PapakyriakouA.KokkalaP.et al (2015)

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A weight of -1 was assigned to genes (or proteins) that inhibit the direction of signal transmission in the pathway to reflect the inhibitory effect

In particular, the intraperitoneal administration of K1K1 resulted in a strong neuroprotective activity on motor neurons in ALS animal models (Vallarola et al., 2020)