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The treatment with Lp-Sav-BL-SN, in contrast, only led to a limited reduction of IC 50 in CNE-1 and CNE-2 cells (Supplementary Fig

Funding This work was funded by the Coimbra Chemistry Centre, which is supported by the Fundao para a Cincia e a Tecnologia (FCT) through the programmes UID/QUI/00313/2020 and COMPETE, and PhD grant (SFR/BD/146358/2019), and also by the project BIOSHELL, Ref

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Therefore, the effects of these two systems on HIFs and NRF2 signaling systems are complex, implying the presence of a network connecting these two systems

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