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Am J Hum Genet 2007;80:407-15.ArticlePubMedPMC 61

Victorelli FD, Manni LS, Biffi S, et al

doi:10.1073/pnas.0709487104

Goetze, S

While glutamine and aspartate act as the nitrogen source for both nucleobases (N1 from aspartate and N3 and N9 from glutamine) and the amino group of purines (glutamine for adenine and aspartate for guanine), glycine can contribute to purine biosynthesis in two ways: by direct incorporation into the purine backbone (C4, C5, and N7) or by producing one-carbon units for biochemical reactions involved in purine biosynthesis (C2 and C8) (Fig