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Specific inhibition of HK2 with 3-bromopyruvate reduces joint swelling and histological damage in SKG mice, a RA model, by suppressing glycolysis-dependent dendritic cell activation and Th17/Treg imbalance

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However, unlike pro-fibrotic agents, GHK-Cu also upregulates the activity of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), facilitating the breakdown of scarred or disorganized collagen

Science 212:541542 Trickler D, Shklar G, Schwartz J (1993) Inhibition of oral carcinogenesis by glutathione