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Furthermore, several disadvantages and constraints, namely low solubility, unstable bioactivity, and truncated circulation half-life of bioactive molecules (e.g., growth factors, cytokines, inhibitors, genes, drugs, etc.), as well as contrast agents, have positioned NPs as among the most appropriate alternatives for the delivery and monitoring of bioactive agents in various applications (124, 197)

Activation and nuclear translocation of the primary transcription factor Nrf2 promote the expression of these enzymes, providing robust protection against oxidative damage [44]

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