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However, the clinical translation of these candidate biomarkers remains incomplete, mainly limited by insufficient detection sensitivity caused by lowfrequency mutations and intratumoral heterogeneity, the lack of standardized cutoff definitions, and a predominance of retrospective studies with scarce prospective validation evidence

Journal of analytical oncology

Supplementation should always be integrated into a broader protocol that includes aggressive pacing to manage post-exertional malaise, careful symptom tracking, dietary modifications to support histamine clearance, and ongoing medical care from specialists who truly understand the interconnected nature of neuro-immune diseases

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[129] The introduction of the first widely used antipsychotic, chlorpromazine (Thorazine), in the 1950s, led to the release of many patients with schizophrenia from institutions in the years that followed