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Description

These agents stimulate parietal cells to rapidly secrete hydrochloric acid

doi: 10.1038/nri2506 95

DES adds the localized punch to stubborn body parts

mobile phase A1:1 mixture of 10 mM ammonium formate, pH 3.0 and acetonitrile and mobile phase B9:1 mixture of acetonitrile and 10 mM ammonium formate, pH 3.0 (01 min, 70% B

This explains the off-target damage observed in tissues with high turnover rates, particularly the gastrointestinal mucosa, bone marrow, and hair follicles